RESEARCH FIELDBiological sciences › BiologyMedical sciences › MedicineTechnology › Biotechnology
RESEARCHER PROFILEFirst Stage Researcher (R1)
APPLICATION DEADLINE30/11/2019 20:00 - Europe/Brussels
LOCATIONNetherlands › Maastricht
TYPE OF CONTRACTTemporary
HOURS PER WEEK40
OFFER STARTING DATE01/01/2020
EU RESEARCH FRAMEWORK PROGRAMMEH2020 / Marie Skłodowska-Curie Actions
MARIE CURIE GRANT AGREEMENT NUMBER813716
Maastricht University is looking for an Early Stage Researchers (ESRs). The ESR (TRAIN-HEART ESR project 9) will functionally characterise non coding RNA candidates as therapeutic targets in ischemic heart failure. The ESR position is a part of the TRAIN-HEART consortium, a Marie-Sklodowska Curie Innovative Training Network that started on the 1st of June 2019.
ABOUT MAASTRICHT UNIVERSITY
Maastricht University is the youngest and most international university in the Netherlands. Ranked 7 in QS “Top 50 under 50”, the university has more than 16,500 students, 4,000 staff and 55,000 alumni, with >70% foreign PhD students and >100 student nationalities. The departments of Molecular Cardiology and Genetic Epidemiology participate in the TRAIN-HEART consortium bringing together over 25 years of experience in the field of cardiac gene regulatory mechanisms and genomics in cardiovascular disease. Prof. Monika Stoll and Prof. Leon de Windt will be supervising the ESR projects at Maastricht University.
The TRAIN-HEART consortium, funded by the European Commission (2019-2023), is made up to train the next-generation of innovation-minded researchers who are able to explore and translate pathogenic insights, accelerate the development of existing RNA therapeutics, and effectively implement innovative drug delivery systems to improve safety and therapeutic efficacy for the treatment of ischemic heart failure. Academic, clinical and industry partners, covering various disciplines ranging from cardiovascular biology to clinical pharmacology and functional genomics to drug development, have teamed up in the EU:
- Maastricht University (The Netherlands)
- Hannover Medical School (Germany)
- King’s College London (United Kingdom)
- Claude Bernard Lyon University (France)
- Technical University Munich (Germany)
- Humanitas University (Milan, Italy)
- University Hospital Hamburg (Germany)
- University of Porto (Portugal)
- Mirabilis Therapeutics BV (Maastricht, The Netherlands)
- Miltenyi Biotec (Cologne, Germany).
TRAIN-HEART website url: http://www.train-heart.eu
ABOUT THE ESR PROJECTS
The PhD students will be enrolled in the CARIM School for Cardiovascular Diseases at the Faculty of Health, Medicine and Life Sciences of Maastricht University and guided by two accredited supervisors.
TRAIN-HEART ESR PROJECT 9
- Main supervisor: Prof. Leon de Windt.
- Co-supervisor: Dr Paula da Costa Martins.
This PhD student will uncover the mechanistic basis for ncRNA candidates in hearts from gain- and loss-of-function mouse models by bioinformatics approaches, target-prediction algorithms, advanced cardiovascular proteomic analysis and high throughput sequencing coupled to argonaute-IP-based approaches to define the cell-type specific targetome of therapeutically relevant ncRNA interactomes. The main result of this project will be the functional characterisation and relevant interactomes of non coding RNA candidates as therapeutic targets in ischemic heart failure in vivo
Secondments: This PhD student will have the opportunity to spend 3 months at King’s College London, United Kingdom (group of Prof. Manuel Mayr, Cardiovascular Proteomics) to acquire skills in state-of-the-art cardiovascular proteomic analyses. Another non-academic secondment opportunity is proposed for 2 months at Descin BV (The Netherlands). This Amsterdam-based company is a focused provider of Horizon 2020 proposal development and project management services. Descin works with research-intensive university and commercial sectors to support research collaboration, enterprise, and knowledge-based business development.
The per annum MSCA PhD student living and mobility allowance (plus family allowance if applicable, family status is assessed at recruitment) is in line with EU-MSCA requirements. This amount will be subject to tax and employee’s National insurance deductions and will be paid in EURO.
Applicants can be of any nationality and must be Early Stage Researchers and shall at the date of recruitment by Maastricht University, be in the first four years (full-time equivalent research experience) of their research careers and have not been awarded a doctoral degree. Furthermore. the applicant must not have resided or carried out his/her main activity (work, studies, etc) in the country of his/her host organisation for more than 12 months in the 3 years immediately prior to his/her recruitment.
HOW TO APPLY
Complete applications in English should include the TRAIN-HEART Application Form and its mandatory attachments (http://train-heart.eu/apply-for-a-train-heart-position). Please note that applications that do not meet these requirements WILL NOT BE CONSIDERED.
Please send the complete package as 1 PDF file via email to email@example.com before 1 November 2019 18:00h - Europe/Brussels.
Please familiarize yourself with the TRAIN-HEART consortium (www.train-heart.eu). Selected applicants will be invited to a following face-to-face interview round. Awarding decisions will be announced shortly thereafter, and candidates are expected to be available to start their projects between December 2019 and March 2020.
Web site for additional job details
TRAIN-HEART ESR project 9
We expect a Master´s degree (or equivalent) in Health and/or Life Sciences. Furthermore, the applicant should be able to perform team-oriented as well as independent work.
Desirable methodological skills: excellent background in molecular biology and/or (small) animal research and/or hands-on knowledge of advanced laboratory methods.
TRAIN-HEART ESR project 9
REQUIRED EDUCATION LEVEL
A degree (MSc, or equivalent) in Health or Life Sciences (Biomedical Sciences, Molecular/Cell Biology) or closely related fields. Candidates in the final stages of obtaining their degree are eligible to apply.
ENGLISH: Excellent, both written and spoken.
EURAXESS offer ID: 403782
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