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21/02/2020

PhD student position in ubiquitin biology and targeted degradation (MSCA)

Categories: News

Tags: PhD | MSCA ITN | Horizon 2020 | Biology


A PhD position is now available within the Division of Clinical Physiology which is funded by the Marie Skłodowska -Curie Action, Innovative Training Networks (MSCA-ITN) within the Horizon 2020 programme of the European Union.

The opening is within the research team led by Dr. Mikael Altun. The division of clinical physiology aims to increase awareness of the link between physical activity and health, and the causes of impaired body function such as muscle wasting during disease or ageing. The research would be conducted in close collaboration with the clinical physiology department at the Karolinska University Hospital.

The biological focus within the research team is the ubiquitin proteasome system (UPS) in basic and translational aspects. In addition, the efforts are concentrated on developing novel molecular, chemical, and biophysical technologies to gain insight into complex cellular processes, such as sensor systems for cellular target engagement to state-of-the-art molecular biology tools. A spin-off with translational potential is to “hijack” the UPS for targeted protein degradation with small molecules or PROTACs (proteolysis-targeting chimeras), which have the potential to create novel therapeutic strategies.

The overall aim of the PhD program will be to understand targeted degradation and create state-of-the-art tools and sensors that can unravel drug or e.g. hormone interaction in cancer, where the student will be able to apply the technologies created within the ITN-CANCERPREV program. The candidate will have the opportunity within the CANCERPREV to get a deep understanding in inflammation and cancer biology.

In the laboratory of Dr. Altun, the candidate will be:

  • trained in basic research within ubiquitin biology
  • trained in translational research part of the next generation drug development
    part of collaborations with the pharmaceutical industry
  • exposed to the clinical needs through the close interaction with the Karolinska University Hospital

For more details click here.